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Home - Products - Wnt/Notch/Hedgehog - Beta-catenin - CCT-031374 hydrobromide

CCT-031374 hydrobromide

CAS No. 1219184-91-4

CCT-031374 hydrobromide( CCT031374 hydrobromide )

Catalog No. M10825 CAS No. 1219184-91-4

A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CCT-031374 hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay.
  • Description
    A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay; promotes β-catenin degradation and lowers β-catenin levels in mouse L-cells, blockes the growth of a number of cancer cell lines including SW480 colon cancer cells (IC50=13.2 uM); blocks free β-catenin levels in BIO-stimulated HEK293 cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CCT031374 hydrobromide
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Beta-catenin
  • Recptor
    Beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1219184-91-4
  • Formula Weight
    434.33
  • Molecular Formula
    C23H19N3O.HBr
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br
  • Chemical Name
    1-([1,1'-biphenyl]-4-yl)-2-(2,3-dihydro-9H-benzo[d]imidazo[1,2-a]imidazol-9-yl)ethan-1-one hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73. 2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91. 3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82.
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